In 857 A.D., in the Rhine Valley, an outbreak of a disease causing hallucinations, gangrene, and death occurred. Because the symptoms included a severe burning sensation, and it was believed to be a punishment from God, it came to be known as Holy Fire. Though a doctor in 1670 figured out the cause, outbreaks would occur for another 170 years before the cause of the disease was finally proven.
Howard Hughes was an eccentric billionaire, record-setting pilot, engineer, film producer, and philanthropist. He was one of the wealthiest and most influential person in the world. Eventually his eccentricity gave way to extreme reclusiveness, obsessive compulsive disorder, and chronic pain.
Ergot of Rye
Ergot – Wikipedia
Has Ergot Altered Events in World History?